The Instrument Automation device works specifically with Plugins, so if you want to send changes to an instrument’s Sample or MIDI components then you should use either the Instrument Macros device or the Instrument MIDI Control device. Instead of working through MIDI, the Instrument Automation device sends parameter changes directly to a Plugin instrument. Selecting the target instrument with the top option will cause the device to be automatically populated with the Plugin’s changeable parameters. Since every Plugin is different, the number and function of parameters available to you can vary wildly. Initially only four parameters are displayed, but the small arrow button in the bottom-right corner will expand the device to show more up to 35, which is the maximum that can be addressed via Effect Commands. Some of the more complex Plugin instruments can have a lot more parameters than that, so to help with this each of the options is actually a drop down menu. Clicking on one will open up a list of all the available parameters, allowing you to select and use the one you need.